Autoimmune Wellness Panel

Ankylosing Spondylitis

Chronic inflammatory arthritis of the sacroiliac joints and spine, with morning stiffness lasting over 30 minutes that improves with activity, and possible spinal fusion in late stages.

Reactive Arthritis

Arthritis triggered 1-4 weeks after a gut or genitourinary infection, classically the triad of arthritis, conjunctivitis and urethritis, usually in asymmetric large joints of the legs.

Psoriatic Arthritis

Around 10-30% of people with psoriasis develop joint disease, which may present as distal interphalangeal arthritis, dactylitis and nail changes — sometimes before any skin symptoms.

Undifferentiated Spondyloarthropathy

Features of spondyloarthropathy that do not yet meet the criteria for a specific subtype, with inflammatory back pain, enthesitis and dactylitis; HLA-B27 positive patients more often progress to ankylosing spondylitis.

Juvenile Idiopathic Arthritis

Chronic arthritis starting before age 16 and lasting over six weeks. The HLA-B27-related subtype is mainly enthesitis-related arthritis, most common in boys aged 8-15.

IBD-associated Arthritis

The most common extraintestinal manifestation of inflammatory bowel disease, affecting 10-35% of patients; axial involvement is strongly associated with HLA-B27.

Uveitis

Inflammation of the uvea. HLA-B27-related disease is usually acute, anterior and unilateral with frequent relapses, and can cause glaucoma and permanent vision loss if untreated.

Celiac Disease

A gluten-driven autoimmune disease causing villous atrophy and malabsorption. Over 95% of patients carry HLA-DQ2 or DQ8, and iron-deficiency anaemia is often the first sign.