Cancer Wellness Panel

Hereditary Breast Cancer

BRCA1 carriers face a lifetime risk of about 60-80% and BRCA2 carriers 40-70%, far above the 12% general population risk, with markedly earlier onset.

Ovarian Cancer

Known as the "silent killer" because early disease has almost no symptoms; lifetime risk is about 40-60% for BRCA1 carriers and 15-25% for BRCA2.

Fallopian Tube Cancer

Many BRCA-related tumours once diagnosed as ovarian cancer in fact begin at the fallopian tube fimbriae, so the two are managed as one disease spectrum.

Primary Peritoneal Carcinoma

Arises on the peritoneal surface but is pathologically identical to BRCA-related ovarian cancer; a 1-4% lifetime risk remains even after risk-reducing salpingo-oophorectomy.

Male Breast Cancer

Rare, but BRCA2 raises a man's lifetime risk to 5-10% — roughly 80-100 times the general male risk — and low awareness often delays diagnosis.

Prostate Cancer

BRCA2 carriers have a lifetime risk of about 20-30%, and their tumours are more aggressive and more likely to metastasise, so earlier PSA screening is advised.

Pancreatic Cancer

BRCA2 carriers have a lifetime risk of about 3-7%, several times that of the general population. Early disease is almost symptomless and over 80% of cases are advanced at diagnosis.

Li-Fraumeni Syndrome

A high-penetrance hereditary cancer syndrome caused by germline TP53 variants, with cumulative lifetime cancer risk up to 90% in women and 73% in men, very early onset and multiple primary tumours.

Osteosarcoma

The most common malignant bone tumour in Li-Fraumeni syndrome, typically around the knee, presenting as bone pain that is worse at night plus local swelling.

Soft Tissue Sarcoma

Includes rhabdomyosarcoma and malignant peripheral nerve sheath tumour among other subtypes; one of the most common LFS tumours, usually a rapidly growing painless lump.

Adrenocortical Carcinoma

Li-Fraumeni syndrome accounts for 50-80% of childhood adrenocortical carcinoma. The tumour may oversecrete steroid hormones, producing Cushing's syndrome or virilisation.

Brain Tumors

LFS-related brain tumours are mainly astrocytoma and choroid plexus tumour, with earlier onset and high sensitivity to radiotherapy.